The Role of Deoxycytidine Kinase (dCK) in Radiation-Induced Cell Death

The Role of Deoxycytidine Kinase (dCK) in Radiation-Induced Cell Death

Deoxycytidine kinase (dCK) is a key enzyme in deoxyribonucleoside salvage and the anti-tumor activity for many nucleoside analogs. dCK is activated in response to ionizing radiation (IR)-induced DNA damage and it is phosphorylated on Serine 74 by the Ataxia-Telangiectasia Mutated (ATM) kinase in ord...

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Bibliographic Details
Main Authors: Rui Zhong, Rui Xin, Zongyan Chen, Nan Liang, Yang Liu, Shumei Ma, Xiaodong Liu
Format: Article
Language:English
Published: MDPI AG 2016-11-01
Series:International Journal of Molecular Sciences
Subjects:
deoxycytidine kinase (dCK)
autophagy
apoptosis
mitotic catastrophe
radiation
Online Access:http://www.mdpi.com/1422-0067/17/11/1939

Internet

http://www.mdpi.com/1422-0067/17/11/1939

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