Microsomal prostaglandin E synthase-1 is a critical factor in dopaminergic neurodegeneration in Parkinson's disease

Microsomal prostaglandin E synthase-1 is a critical factor in dopaminergic neurodegeneration in Parkinson's disease

Parkinson's disease (PD) is a neurodegenerative disorder of uncertain pathogenesis characterized by the loss of nigrostriatal dopaminergic neurons. Although increased production of prostaglandin E2 (PGE2) has been implicated in tissue damage in several pathological settings, the role of microso...

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Bibliographic Details
Main Authors: Yuri Ikeda-Matsuo, Hajime Miyata, Tomoko Mizoguchi, Eisaku Ohama, Yasuhito Naito, Satoshi Uematsu, Shizuo Akira, Yasuharu Sasaki, Mitsuo Tanabe
Format: Article
Language:English
Published: Elsevier 2019-04-01
Series:Neurobiology of Disease
Subjects:
Parkinson's disease
Neurodegeneration
Prostaglandin E2
Microsomal prostaglandin E synthase
Neuroinflammation
Dopamine
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996118307411

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http://www.sciencedirect.com/science/article/pii/S0969996118307411

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