Nonsense-mediated decay mechanism is a possible modifying factor of clinical outcome in nonsense cd39 beta thalassemia genotype
<p>Nonsense-mediated mRNA decay (NMD) is a surveillance system to prevent the synthesis of non-functional proteins. In β-thalassemia, NMD may have a role in clinical outcome. An example of premature translation stop codons appearing for the first time is the β-globin cd39 mut...
Main Authors: | Maria Concetta Renda, Angela Vitrano, Massimo Attanasio, Emanuela Fecarotta, Angela Piazza, Antonino Giambona, Germana Fiorentino, Disma Renda, Paolo Rigano, Giuseppina Calvaruso, Filippo Cassarà, Aurelio Maggio |
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Format: | Article |
Language: | English |
Published: |
PAGEPress Publications
2012-11-01
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Series: | Thalassemia Reports |
Subjects: | |
Online Access: | http://www.pagepressjournals.org/index.php/thal/article/view/497 |
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