Multi-tissue computational modeling analyzes pathophysiology of type 2 diabetes in MKR mice.

Multi-tissue computational modeling analyzes pathophysiology of type 2 diabetes in MKR mice.

Computational models using metabolic reconstructions for in silico simulation of metabolic disorders such as type 2 diabetes mellitus (T2DM) can provide a better understanding of disease pathophysiology and avoid high experimentation costs. There is a limited amount of computational work, using meta...

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Bibliographic Details
Main Authors: Amit Kumar, Thomas Harrelson, Nathan E Lewis, Emily J Gallagher, Derek LeRoith, Joseph Shiloach, Michael J Betenbaugh
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4100879?pdf=render

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http://europepmc.org/articles/PMC4100879?pdf=render

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