The mTORC1 complex in pre-osteoblasts regulates whole-body energy metabolism independently of osteocalcin

The mTORC1 complex in pre-osteoblasts regulates whole-body energy metabolism independently of osteocalcin

Abstract Overnutrition causes hyperactivation of mTORC1-dependent negative feedback loops leading to the downregulation of insulin signaling and development of insulin resistance. In osteoblasts (OBs), insulin signaling plays a crucial role in the control of systemic glucose homeostasis. We utilized...

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Bibliographic Details
Main Authors: Pawanrat Tangseefa, Sally K. Martin, Peck Yin Chin, James Breen, Chui Yan Mah, Paul A. Baldock, Gary A. Wittert, Amanda J. Page, Christopher G. Proud, Stephen Fitter, Andrew C. W. Zannettino
Format: Article
Language:English
Published: Nature Publishing Group 2021-02-01
Series:Bone Research
Online Access:https://doi.org/10.1038/s41413-020-00123-z

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https://doi.org/10.1038/s41413-020-00123-z

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