Molecular Dysfunctions of Mitochondria-Associated Endoplasmic Reticulum Contacts in Atherosclerosis
Atherosclerosis is a chronic lipid-driven inflammatory disease that results in the formation of lipid-rich and immune cell-rich plaques in the arterial wall, which has high morbidity and mortality in the world. The mechanism of atherosclerosis is still unclear now. Potential hypotheses involved in a...
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Series: | Oxidative Medicine and Cellular Longevity |
Online Access: | http://dx.doi.org/10.1155/2021/2424509 |
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doaj-2606f21d5b7e4b379052018c553c17022021-08-02T00:01:20ZengHindawi LimitedOxidative Medicine and Cellular Longevity1942-09942021-01-01202110.1155/2021/2424509Molecular Dysfunctions of Mitochondria-Associated Endoplasmic Reticulum Contacts in AtherosclerosisXiaojiao Wang0Dan Luo1Sisi Wu2Core Facilities of West China HospitalCore Facilities of West China HospitalCore Facilities of West China HospitalAtherosclerosis is a chronic lipid-driven inflammatory disease that results in the formation of lipid-rich and immune cell-rich plaques in the arterial wall, which has high morbidity and mortality in the world. The mechanism of atherosclerosis is still unclear now. Potential hypotheses involved in atherosclerosis are chronic inflammation theory, lipid percolation theory, mononuclear-macrophage theory, endothelial cell (EC) injury theory, and smooth muscle cell (SMC) mutation theory. Changes of phospholipids, glucose, critical proteins, etc. on mitochondria-associated endoplasmic reticulum membrane (MAM) can cause the progress of atherosclerosis. This review describes the structural and functional interaction between mitochondria and endoplasmic reticulum (ER) and explains the role of critical molecules in the structure of MAM during atherosclerosis.http://dx.doi.org/10.1155/2021/2424509 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Xiaojiao Wang Dan Luo Sisi Wu |
spellingShingle |
Xiaojiao Wang Dan Luo Sisi Wu Molecular Dysfunctions of Mitochondria-Associated Endoplasmic Reticulum Contacts in Atherosclerosis Oxidative Medicine and Cellular Longevity |
author_facet |
Xiaojiao Wang Dan Luo Sisi Wu |
author_sort |
Xiaojiao Wang |
title |
Molecular Dysfunctions of Mitochondria-Associated Endoplasmic Reticulum Contacts in Atherosclerosis |
title_short |
Molecular Dysfunctions of Mitochondria-Associated Endoplasmic Reticulum Contacts in Atherosclerosis |
title_full |
Molecular Dysfunctions of Mitochondria-Associated Endoplasmic Reticulum Contacts in Atherosclerosis |
title_fullStr |
Molecular Dysfunctions of Mitochondria-Associated Endoplasmic Reticulum Contacts in Atherosclerosis |
title_full_unstemmed |
Molecular Dysfunctions of Mitochondria-Associated Endoplasmic Reticulum Contacts in Atherosclerosis |
title_sort |
molecular dysfunctions of mitochondria-associated endoplasmic reticulum contacts in atherosclerosis |
publisher |
Hindawi Limited |
series |
Oxidative Medicine and Cellular Longevity |
issn |
1942-0994 |
publishDate |
2021-01-01 |
description |
Atherosclerosis is a chronic lipid-driven inflammatory disease that results in the formation of lipid-rich and immune cell-rich plaques in the arterial wall, which has high morbidity and mortality in the world. The mechanism of atherosclerosis is still unclear now. Potential hypotheses involved in atherosclerosis are chronic inflammation theory, lipid percolation theory, mononuclear-macrophage theory, endothelial cell (EC) injury theory, and smooth muscle cell (SMC) mutation theory. Changes of phospholipids, glucose, critical proteins, etc. on mitochondria-associated endoplasmic reticulum membrane (MAM) can cause the progress of atherosclerosis. This review describes the structural and functional interaction between mitochondria and endoplasmic reticulum (ER) and explains the role of critical molecules in the structure of MAM during atherosclerosis. |
url |
http://dx.doi.org/10.1155/2021/2424509 |
work_keys_str_mv |
AT xiaojiaowang moleculardysfunctionsofmitochondriaassociatedendoplasmicreticulumcontactsinatherosclerosis AT danluo moleculardysfunctionsofmitochondriaassociatedendoplasmicreticulumcontactsinatherosclerosis AT sisiwu moleculardysfunctionsofmitochondriaassociatedendoplasmicreticulumcontactsinatherosclerosis |
_version_ |
1721245221071618048 |