Comprehensive Profiling of Mutations to Influenza Virus PB2 That Confer Resistance to the Cap-Binding Inhibitor Pimodivir

Comprehensive Profiling of Mutations to Influenza Virus PB2 That Confer Resistance to the Cap-Binding Inhibitor Pimodivir

Antivirals are used not only in the current treatment of influenza but are also stockpiled as a first line of defense against novel influenza strains for which vaccines have yet to be developed. Identifying drug resistance mutations can guide the clinical deployment of the antiviral and can addition...

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Bibliographic Details
Main Authors: Y. Q. Shirleen Soh, Keara D. Malone, Rachel T. Eguia, Jesse D. Bloom
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Viruses
Subjects:
influenza
drug resistance
pimodivir
PB2
polymerase
deep mutational scanning
Online Access:https://www.mdpi.com/1999-4915/13/7/1196

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