Mitochondria and metabolic transitions in cardiomyocytes: lessons from development for stem cell-derived cardiomyocytes

Mitochondria and metabolic transitions in cardiomyocytes: lessons from development for stem cell-derived cardiomyocytes

Abstract Current methods to differentiate cardiomyocytes from human pluripotent stem cells (PSCs) inadequately recapitulate complete development and result in PSC-derived cardiomyocytes (PSC-CMs) with an immature or fetal-like phenotype. Embryonic and fetal development are highly dynamic periods dur...

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Bibliographic Details
Main Authors: Jessica C. Garbern, Richard T. Lee
Format: Article
Language:English
Published: BMC 2021-03-01
Series:Stem Cell Research & Therapy
Subjects:
Stem cells
Cardiomyocytes
Mitochondria
Maturation
Metabolic regulation
Online Access:https://doi.org/10.1186/s13287-021-02252-6

Internet

https://doi.org/10.1186/s13287-021-02252-6

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