Adrenergic Agonists Bind to Adrenergic-Receptor-Like Regions of the Mu Opioid Receptor, Enhancing Morphine and Methionine-Enkephalin Binding: A New Approach to “Biased Opioids”?

Adrenergic Agonists Bind to Adrenergic-Receptor-Like Regions of the Mu Opioid Receptor, Enhancing Morphine and Methionine-Enkephalin Binding: A New Approach to “Biased Opioids”?

Extensive evidence demonstrates functional interactions between the adrenergic and opioid systems in a diversity of tissues and organs. While some effects are due to receptor and second messenger cross-talk, recent research has revealed an extracellular, allosteric opioid binding site on adrenergic...

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Bibliographic Details
Main Authors: Robert Root-Bernstein, Miah Turke, Udaya K. Tiruttani Subhramanyam, Beth Churchill, Joerg Labahn
Format: Article
Language:English
Published: MDPI AG 2018-01-01
Series:International Journal of Molecular Sciences
Subjects:
biased opioids
morphine
methionine-enkephalin
epinephrine
norepinephrine
enhancement
synergy
allosteric
mu opioid receptor
receptor dimers
dimerization
Online Access:http://www.mdpi.com/1422-0067/19/1/272

Internet

http://www.mdpi.com/1422-0067/19/1/272

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