Epidemiology of heart failure in pediatric populations in low- and middle-income countries: a protocol for a systematic review

Abstract Background Heart failure (HF) in pediatric populations is a major public health concern. It is associated with high rates of hospital admissions, disability, and mortality in high-income countries (HIC), but its burden is poorly documented in low- and middle-income countries (LMICs). We pre...

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Main Authors: Aurélie T. Sibetcheu, Valirie Ndip Agbor, Ulrich Flore Nyaga, Jean Joël Bigna, Jean Jacques Noubiap
Format: Article
Language:English
Published: BMC 2018-04-01
Series:Systematic Reviews
Subjects:
Online Access:http://link.springer.com/article/10.1186/s13643-018-0717-6
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spelling doaj-26f241b566a243f9b2e0e409cdab9a9b2020-11-25T01:29:14ZengBMCSystematic Reviews2046-40532018-04-01711610.1186/s13643-018-0717-6Epidemiology of heart failure in pediatric populations in low- and middle-income countries: a protocol for a systematic reviewAurélie T. Sibetcheu0Valirie Ndip Agbor1Ulrich Flore Nyaga2Jean Joël Bigna3Jean Jacques Noubiap4Department of Paediatrics, Faculty of Medicine and Biomedical Sciences, University of Yaoundé 1Ibal Sub-Divisional HospitalDepartment of Internal Medicine and Specialties, Faculty of Medicine and Biomedical Sciences, University of Yaoundé 1Department of Epidemiology and Public Health, Centre Pasteur of CameroonDepartment of Medicine, University of Cape Town, Groote Schuur HospitalAbstract Background Heart failure (HF) in pediatric populations is a major public health concern. It is associated with high rates of hospital admissions, disability, and mortality in high-income countries (HIC), but its burden is poorly documented in low- and middle-income countries (LMICs). We present a protocol for a systematic review and meta-analysis to summarize available data on the prevalence, incidence, etiologies, treatment, and outcomes including hospital admission and mortality and economic burden of HF in neonates, infants, children, and adolescents in LMICs. Methods A comprehensive search of articles published between January 01, 2000, and December 31, 2017, will be performed in PubMed/MEDLINE, EMBASE, Global Index Medicus, and Web of Science. All cross-sectional, cohort studies and case-control studies reporting on the prevalence, incidence, etiologies, treatment, prognosis, admission rates, mortality, and economic burden of HF in pediatric populations in LMICs will be included in the review. The methodological quality of included studies will be appraised accordingly. For prognosis data, the Quality in Prognosis Studies (QUIPS) tool will be used. The symmetry of funnel plot and Egger’s test will be used to identify publication bias. An overall summary estimate of prevalence/incidence of pediatric HF across studies will be obtained from study-specific estimates pooled through a random-effect model. Heterogeneity of studies will be assessed by the χ 2 test on Cochrane’s Q statistic. A p value less than 0.05 will be considered significant for factors that predict mortality. This systematic review and meta-analysis will be reported following the PRISMA guidelines. Discussion This study will report and summarize epidemiology data, as well as the economic burden of HF in neonates, infants, children, and adolescents of LMICs. Limitations will mainly arise from the heterogeneity in the diagnostic of HF. Systematic review registration PROSPERO CRD42017070189.http://link.springer.com/article/10.1186/s13643-018-0717-6EpidemiologyPrevalenceIncidenceEtiologyTreatmentMortality
collection DOAJ
language English
format Article
sources DOAJ
author Aurélie T. Sibetcheu
Valirie Ndip Agbor
Ulrich Flore Nyaga
Jean Joël Bigna
Jean Jacques Noubiap
spellingShingle Aurélie T. Sibetcheu
Valirie Ndip Agbor
Ulrich Flore Nyaga
Jean Joël Bigna
Jean Jacques Noubiap
Epidemiology of heart failure in pediatric populations in low- and middle-income countries: a protocol for a systematic review
Systematic Reviews
Epidemiology
Prevalence
Incidence
Etiology
Treatment
Mortality
author_facet Aurélie T. Sibetcheu
Valirie Ndip Agbor
Ulrich Flore Nyaga
Jean Joël Bigna
Jean Jacques Noubiap
author_sort Aurélie T. Sibetcheu
title Epidemiology of heart failure in pediatric populations in low- and middle-income countries: a protocol for a systematic review
title_short Epidemiology of heart failure in pediatric populations in low- and middle-income countries: a protocol for a systematic review
title_full Epidemiology of heart failure in pediatric populations in low- and middle-income countries: a protocol for a systematic review
title_fullStr Epidemiology of heart failure in pediatric populations in low- and middle-income countries: a protocol for a systematic review
title_full_unstemmed Epidemiology of heart failure in pediatric populations in low- and middle-income countries: a protocol for a systematic review
title_sort epidemiology of heart failure in pediatric populations in low- and middle-income countries: a protocol for a systematic review
publisher BMC
series Systematic Reviews
issn 2046-4053
publishDate 2018-04-01
description Abstract Background Heart failure (HF) in pediatric populations is a major public health concern. It is associated with high rates of hospital admissions, disability, and mortality in high-income countries (HIC), but its burden is poorly documented in low- and middle-income countries (LMICs). We present a protocol for a systematic review and meta-analysis to summarize available data on the prevalence, incidence, etiologies, treatment, and outcomes including hospital admission and mortality and economic burden of HF in neonates, infants, children, and adolescents in LMICs. Methods A comprehensive search of articles published between January 01, 2000, and December 31, 2017, will be performed in PubMed/MEDLINE, EMBASE, Global Index Medicus, and Web of Science. All cross-sectional, cohort studies and case-control studies reporting on the prevalence, incidence, etiologies, treatment, prognosis, admission rates, mortality, and economic burden of HF in pediatric populations in LMICs will be included in the review. The methodological quality of included studies will be appraised accordingly. For prognosis data, the Quality in Prognosis Studies (QUIPS) tool will be used. The symmetry of funnel plot and Egger’s test will be used to identify publication bias. An overall summary estimate of prevalence/incidence of pediatric HF across studies will be obtained from study-specific estimates pooled through a random-effect model. Heterogeneity of studies will be assessed by the χ 2 test on Cochrane’s Q statistic. A p value less than 0.05 will be considered significant for factors that predict mortality. This systematic review and meta-analysis will be reported following the PRISMA guidelines. Discussion This study will report and summarize epidemiology data, as well as the economic burden of HF in neonates, infants, children, and adolescents of LMICs. Limitations will mainly arise from the heterogeneity in the diagnostic of HF. Systematic review registration PROSPERO CRD42017070189.
topic Epidemiology
Prevalence
Incidence
Etiology
Treatment
Mortality
url http://link.springer.com/article/10.1186/s13643-018-0717-6
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