Structural basis for human ZBTB7A action at the fetal globin promoter

Structural basis for human ZBTB7A action at the fetal globin promoter

Summary: Elevated levels of fetal globin protect against β-hemoglobinopathies, such as sickle cell disease and β-thalassemia. Two zinc-finger (ZF) repressors, BCL11A and ZBTB7A/LRF, bind directly to the fetal globin promoter elements positioned at −115 and −200, respectively. Here, we describe X-ray...

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Bibliographic Details
Main Authors: Yang Yang, Ren Ren, Lana C. Ly, John R. Horton, Fudong Li, Kate G.R. Quinlan, Merlin Crossley, Yunyu Shi, Xiaodong Cheng
Format: Article
Language:English
Published: Elsevier 2021-09-01
Series:Cell Reports
Subjects:
C2H2 zinc-finger transcription factors
globin gene activation
γ-globin
fetal form of β-globin
globin switching
ZBTB7A
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124721012134

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http://www.sciencedirect.com/science/article/pii/S2211124721012134

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