Clinical observation of glaucoma trabeculectomy with mitomycin C treatment

AIM:To explore the clinical outcome of trabeculectomy with mitomycin C(MMC)on glaucoma. <p>METHODS: A total of 57 patients(95 eyes)of primary glaucoma were randomly divided into two groups, 31 patients(54 eyes)in trabeculectomy with MMC(T+MMC)group, which received trabeculectomy with 0.2mg/mL...

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Main Authors: Shi Liu, Shu-Hui Xing
Format: Article
Language:English
Published: Press of International Journal of Ophthalmology (IJO PRESS) 2014-12-01
Series:Guoji Yanke Zazhi
Subjects:
Online Access:http://ies.ijo.cn/cn_publish/2014/12/201412043.pdf
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spelling doaj-2791b73893724a84bf147fa328bedbcc2020-11-25T01:09:45ZengPress of International Journal of Ophthalmology (IJO PRESS)Guoji Yanke Zazhi1672-51231672-51232014-12-0114122256225810.3980/j.issn.1672-5123.2014.12.43Clinical observation of glaucoma trabeculectomy with mitomycin C treatmentShi Liu0Shu-Hui Xing1Department of Ophthalmology, the Forth People's Hospital of Shaanxi, Xi'an 710043, Shaanxi Province, ChinaDepartment of Ophthalmology, the Forth People's Hospital of Shaanxi, Xi'an 710043, Shaanxi Province, ChinaAIM:To explore the clinical outcome of trabeculectomy with mitomycin C(MMC)on glaucoma. <p>METHODS: A total of 57 patients(95 eyes)of primary glaucoma were randomly divided into two groups, 31 patients(54 eyes)in trabeculectomy with MMC(T+MMC)group, which received trabeculectomy with 0.2mg/mL MMC in surgical sites, and 26 patients(41 eyes)in trabeculectomy(T)group. The anterior chamber, bleb, intraocular pressure(IOP)and complications were observed. The post-operative follow-up periods ranged between 4 and 6mo.<p>RESULTS: The mean IOP was 11.24±3.73mmHg on 1d in group T+MMC. There was the significant difference compared with preoperative IOP(<i>P</i><0.01), while no difference with the group T(<i>P</i>>0.05). At final follow-up, the IOP was significantly different between group T+MMC and group T(16.15±3.62mmHg <i>vs</i> 18.79±5.27mmHg, <i>P</i><0.05). The rate of bleb formation was 94.44% and 80.48% in group T+MMC and T, respectively(<i>P</i><0.01). The postoperative complications were seldom, hyphema and corneal edema, and were cured finally.<p>CONCLUSION: Trabeculectomy with MMC for glaucoma can effectively reduce postoperative scar formation of the filtration passage and lower the IOP to a target level with fewer complications.http://ies.ijo.cn/cn_publish/2014/12/201412043.pdfglaucomatrabeculectomymitomycin C
collection DOAJ
language English
format Article
sources DOAJ
author Shi Liu
Shu-Hui Xing
spellingShingle Shi Liu
Shu-Hui Xing
Clinical observation of glaucoma trabeculectomy with mitomycin C treatment
Guoji Yanke Zazhi
glaucoma
trabeculectomy
mitomycin C
author_facet Shi Liu
Shu-Hui Xing
author_sort Shi Liu
title Clinical observation of glaucoma trabeculectomy with mitomycin C treatment
title_short Clinical observation of glaucoma trabeculectomy with mitomycin C treatment
title_full Clinical observation of glaucoma trabeculectomy with mitomycin C treatment
title_fullStr Clinical observation of glaucoma trabeculectomy with mitomycin C treatment
title_full_unstemmed Clinical observation of glaucoma trabeculectomy with mitomycin C treatment
title_sort clinical observation of glaucoma trabeculectomy with mitomycin c treatment
publisher Press of International Journal of Ophthalmology (IJO PRESS)
series Guoji Yanke Zazhi
issn 1672-5123
1672-5123
publishDate 2014-12-01
description AIM:To explore the clinical outcome of trabeculectomy with mitomycin C(MMC)on glaucoma. <p>METHODS: A total of 57 patients(95 eyes)of primary glaucoma were randomly divided into two groups, 31 patients(54 eyes)in trabeculectomy with MMC(T+MMC)group, which received trabeculectomy with 0.2mg/mL MMC in surgical sites, and 26 patients(41 eyes)in trabeculectomy(T)group. The anterior chamber, bleb, intraocular pressure(IOP)and complications were observed. The post-operative follow-up periods ranged between 4 and 6mo.<p>RESULTS: The mean IOP was 11.24±3.73mmHg on 1d in group T+MMC. There was the significant difference compared with preoperative IOP(<i>P</i><0.01), while no difference with the group T(<i>P</i>>0.05). At final follow-up, the IOP was significantly different between group T+MMC and group T(16.15±3.62mmHg <i>vs</i> 18.79±5.27mmHg, <i>P</i><0.05). The rate of bleb formation was 94.44% and 80.48% in group T+MMC and T, respectively(<i>P</i><0.01). The postoperative complications were seldom, hyphema and corneal edema, and were cured finally.<p>CONCLUSION: Trabeculectomy with MMC for glaucoma can effectively reduce postoperative scar formation of the filtration passage and lower the IOP to a target level with fewer complications.
topic glaucoma
trabeculectomy
mitomycin C
url http://ies.ijo.cn/cn_publish/2014/12/201412043.pdf
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