Mitochondrial ATP transporter depletion protects mice against liver steatosis and insulin resistance

Mitochondrial ATP transporter depletion protects mice against liver steatosis and insulin resistance

Adenine nucleotide translocase (ANT) 2 promotes ADP/ATP exchange across the mitochondrial inner membrane. Choet al. show that liver specific Ant2 deletion increases uncoupled respiration and protects mice against fatty liver and obesity-induced insulin resistance.

Bibliographic Details
Main Authors: Joonseok Cho, Yujian Zhang, Shi-Young Park, Anna-Maria Joseph, Chul Han, Hyo-Jin Park, Srilaxmi Kalavalapalli, Sung-Kook Chun, Drake Morgan, Jae-Sung Kim, Shinichi Someya, Clayton E. Mathews, Young Jae Lee, Stephanie E. Wohlgemuth, Nishanth E. Sunny, Hui-Young Lee, Cheol Soo Choi, Takayuki Shiratsuchi, S. Paul Oh, Naohiro Terada
Format: Article
Language:English
Published: Nature Publishing Group 2017-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms14477

Internet

https://doi.org/10.1038/ncomms14477

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