Mitochondrial ATP transporter depletion protects mice against liver steatosis and insulin resistance
Adenine nucleotide translocase (ANT) 2 promotes ADP/ATP exchange across the mitochondrial inner membrane. Choet al. show that liver specific Ant2 deletion increases uncoupled respiration and protects mice against fatty liver and obesity-induced insulin resistance.
Bibliographic Details
| Main Authors: |
Joonseok Cho,
Yujian Zhang,
Shi-Young Park,
Anna-Maria Joseph,
Chul Han,
Hyo-Jin Park,
Srilaxmi Kalavalapalli,
Sung-Kook Chun,
Drake Morgan,
Jae-Sung Kim,
Shinichi Someya,
Clayton E. Mathews,
Young Jae Lee,
Stephanie E. Wohlgemuth,
Nishanth E. Sunny,
Hui-Young Lee,
Cheol Soo Choi,
Takayuki Shiratsuchi,
S. Paul Oh,
Naohiro Terada |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Publishing Group
2017-02-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/ncomms14477
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