Loss of RANBP3L leads to transformation of renal epithelial cells towards a renal clear cell carcinoma like phenotype

Loss of RANBP3L leads to transformation of renal epithelial cells towards a renal clear cell carcinoma like phenotype

Abstract Background Renal cell carcinomas (RCC) are characterized by the deregulation of several hundred hyperosmolality-responsive genes. High expression of a subset of these genes including the Ran binding protein 3 like (RANBP3L) is linked to a favorable prognostic outcome in RCC. However, the ce...

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Bibliographic Details
Main Authors: Dmitry Chernyakov, Alexander Groß, Annika Fischer, Nicola Bornkessel, Christoph Schultheiss, Dennis Gerloff, Bayram Edemir
Format: Article
Language:English
Published: BMC 2021-07-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Renal cell carcinoma
Tumor progression
Tumor suppressor
CRISPR/Cas9
Hyperosmolality
Online Access:https://doi.org/10.1186/s13046-021-01982-y

Internet

https://doi.org/10.1186/s13046-021-01982-y

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