Loss of neurofibromin Ras-GAP activity enhances the formation of cardiac blood islands in murine embryos

Loss of neurofibromin Ras-GAP activity enhances the formation of cardiac blood islands in murine embryos

Type I neurofibromatosis (NF1) is caused by mutations in the NF1 gene encoding neurofibromin. Neurofibromin exhibits Ras GTPase activating protein (Ras-GAP) activity that is thought to mediate cellular functions relevant to disease phenotypes. Loss of murine Nf1 results in embryonic lethality due to...

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Bibliographic Details
Main Authors: Amanda D Yzaguirre, Arun Padmanabhan, Eric D de Groh, Kurt A Engleka, Jun Li, Nancy A Speck, Jonathan A Epstein
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2015-10-01
Series:eLife
Subjects:
neurofibromin
cardiac blood islands
hemogenic endothelium
GAP-related domain
neural crest
embryo
Online Access:https://elifesciences.org/articles/07780

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