The association between duration of breastfeeding and atopy in children with or without family history of atopic disease

Background Atopic diseases (AD) are the most common chronic diseases in childhood, and their incidence has a tendency to increase recently. Tendency to have atopy could be triggered by many factors originated in early life, including time of breastfeeding cessation. Objective To determine the associ...

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Main Authors: Riana Novy, Budi Setiabudiawan, Cissy B. Kartasasmita
Format: Article
Language:English
Published: Indonesian Pediatric Society Publishing House 2007-08-01
Series:Paediatrica Indonesiana
Subjects:
Online Access:https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/410
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spelling doaj-27d7f5d47c3f407d8f1aa705b1fbcff22020-11-25T01:29:17ZengIndonesian Pediatric Society Publishing HousePaediatrica Indonesiana0030-93112338-476X2007-08-014741798410.14238/pi47.4.2007.179-84301The association between duration of breastfeeding and atopy in children with or without family history of atopic diseaseRiana NovyBudi SetiabudiawanCissy B. KartasasmitaBackground Atopic diseases (AD) are the most common chronic diseases in childhood, and their incidence has a tendency to increase recently. Tendency to have atopy could be triggered by many factors originated in early life, including time of breastfeeding cessation. Objective To determine the association between exclusive and duration of breastfeeding and atopy in children with or without family history of atopic disease. Methods This was an observational clinical epidemiology study performed at Babakansari, Padasuka, Garuda Primary Health Care Center in Bandung from January to March 2006. One hundred fifty of 749 children were randomized from group with and without family history of AD. They underwent skin prick tests and total serum IgE level analysis. Atopy was defined as a positive skin prick test to any of the eight allergens tested. History of exclusive and duration of breastfeeding was obtained from their parents. Significance tests for contingency tables were on the basis of x 2 test for association odds ratio with 95% confidence interval. Results Atopy was found in 28.2% of children, of whom 32.4% with and 23.9% without family history of AD. Children exclusively breastfed exhibited a reduced risk of atopy (5.8% v 35.3%, OR=0.11, 95%CI= 0.03;0.34, P<0.001). The difference of atopy was strongly significant between children who had exclusive breastfeeding and those without exclusive breastfeeding whether or not the subjects had family history of AD (P<0.001). There was a highly significant risk reduction for atopy related to prolonged breastfeeding (=6 months) (OR=0.37, 95%CI = 0.19 to 0.72, P=0.001). The difference of atopy was strongly significant between children who had prolonged breastfeeding and short breastfeeding duration whether or not the subjects had family history of AD (P<0.001) Conclusions Exclusive and prolonged breastfeeding decrease atopy in children with as well as without family history of AD.https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/410Atopyatopic diseasetotal serum IgEbreastfeeding
collection DOAJ
language English
format Article
sources DOAJ
author Riana Novy
Budi Setiabudiawan
Cissy B. Kartasasmita
spellingShingle Riana Novy
Budi Setiabudiawan
Cissy B. Kartasasmita
The association between duration of breastfeeding and atopy in children with or without family history of atopic disease
Paediatrica Indonesiana
Atopy
atopic disease
total serum IgE
breastfeeding
author_facet Riana Novy
Budi Setiabudiawan
Cissy B. Kartasasmita
author_sort Riana Novy
title The association between duration of breastfeeding and atopy in children with or without family history of atopic disease
title_short The association between duration of breastfeeding and atopy in children with or without family history of atopic disease
title_full The association between duration of breastfeeding and atopy in children with or without family history of atopic disease
title_fullStr The association between duration of breastfeeding and atopy in children with or without family history of atopic disease
title_full_unstemmed The association between duration of breastfeeding and atopy in children with or without family history of atopic disease
title_sort association between duration of breastfeeding and atopy in children with or without family history of atopic disease
publisher Indonesian Pediatric Society Publishing House
series Paediatrica Indonesiana
issn 0030-9311
2338-476X
publishDate 2007-08-01
description Background Atopic diseases (AD) are the most common chronic diseases in childhood, and their incidence has a tendency to increase recently. Tendency to have atopy could be triggered by many factors originated in early life, including time of breastfeeding cessation. Objective To determine the association between exclusive and duration of breastfeeding and atopy in children with or without family history of atopic disease. Methods This was an observational clinical epidemiology study performed at Babakansari, Padasuka, Garuda Primary Health Care Center in Bandung from January to March 2006. One hundred fifty of 749 children were randomized from group with and without family history of AD. They underwent skin prick tests and total serum IgE level analysis. Atopy was defined as a positive skin prick test to any of the eight allergens tested. History of exclusive and duration of breastfeeding was obtained from their parents. Significance tests for contingency tables were on the basis of x 2 test for association odds ratio with 95% confidence interval. Results Atopy was found in 28.2% of children, of whom 32.4% with and 23.9% without family history of AD. Children exclusively breastfed exhibited a reduced risk of atopy (5.8% v 35.3%, OR=0.11, 95%CI= 0.03;0.34, P<0.001). The difference of atopy was strongly significant between children who had exclusive breastfeeding and those without exclusive breastfeeding whether or not the subjects had family history of AD (P<0.001). There was a highly significant risk reduction for atopy related to prolonged breastfeeding (=6 months) (OR=0.37, 95%CI = 0.19 to 0.72, P=0.001). The difference of atopy was strongly significant between children who had prolonged breastfeeding and short breastfeeding duration whether or not the subjects had family history of AD (P<0.001) Conclusions Exclusive and prolonged breastfeeding decrease atopy in children with as well as without family history of AD.
topic Atopy
atopic disease
total serum IgE
breastfeeding
url https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/410
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