BK Polyomavirus MicroRNA Levels in Exosomes Are Modulated by Non-Coding Control Region Activity and Down-Regulate Viral Replication When Delivered to Non-Infected Cells Prior to Infection

BK Polyomavirus MicroRNA Levels in Exosomes Are Modulated by Non-Coding Control Region Activity and Down-Regulate Viral Replication When Delivered to Non-Infected Cells Prior to Infection

In immunosuppressed patients, BKPyV-variants emerge carrying rearranged non-coding control-regions (rr-NCCRs) that increase early viral gene region (EVGR) expression and replication capacity. BKPyV also encodes microRNAs, which have been reported to downregulate EVGR-encoded large T-antigen transcri...

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Bibliographic Details
Main Authors: Francesco Martelli, Zongsong Wu, Serena Delbue, Fabian H. Weissbach, Maria Chiara Giulioli, Pasquale Ferrante, Hans H. Hirsch, Simone Giannecchini
Format: Article
Language:English
Published: MDPI AG 2018-08-01
Series:Viruses
Subjects:
polyomavirus
non-coding control region
microRNA
exosomes
persistence
immunosuppression
BK virus
Online Access:http://www.mdpi.com/1999-4915/10/9/466

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http://www.mdpi.com/1999-4915/10/9/466

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