Histone deacetylase inhibitors SAHA and sodium butyrate block G1-to-S cell cycle progression in neurosphere formation by adult subventricular cells

Histone deacetylase inhibitors SAHA and sodium butyrate block G1-to-S cell cycle progression in neurosphere formation by adult subventricular cells

<p>Abstract</p> <p>Background</p> <p>Histone deacetylases (HDACs) are enzymes that modulate gene expression and cellular processes by deacetylating histones and non-histone proteins. While small molecule inhibitors of HDAC activity (HDACi) are used clinically in the tre...

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Bibliographic Details
Main Authors: Doughty Martin L, Wynder Christopher, Dalgard Clifton L, Zhou Qiong
Format: Article
Language:English
Published: BMC 2011-05-01
Series:BMC Neuroscience
Subjects:
suberoylanilide hydroxamic acid
vorinostat
sodium butyrate
cyclin-dependant kinase inhibitor
p21 (Cip1/Waf1/Cdkn1a)
p27 (Kip1/Cdkn1b)
cell cycle
chromatin immunoprecipitation
Online Access:http://www.biomedcentral.com/1471-2202/12/50

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http://www.biomedcentral.com/1471-2202/12/50

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