Stimulation of Replication Template-Switching by DNA-Protein Crosslinks

Stimulation of Replication Template-Switching by DNA-Protein Crosslinks

Covalent DNA protein crosslinks (DPCs) are common lesions that block replication. We examine here the consequence of DPCs on mutagenesis involving replicational template-switch reactions in Escherichia coli. 5-Azacytidine (5-azaC) is a potent mutagen for template-switching. This effect is dependent...

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Bibliographic Details
Main Authors: Laura T. Laranjo, Julie A. Klaric, Leah R. Pearlman, Susan T. Lovett
Format: Article
Language:English
Published: MDPI AG 2018-12-01
Series:Genes
Subjects:
DNA replication
DNA repair
genetic recombination
mutagenesis
Online Access:http://www.mdpi.com/2073-4425/10/1/14

Internet

http://www.mdpi.com/2073-4425/10/1/14

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