A new family of lysozyme inhibitors contributing to lysozyme tolerance in gram-negative bacteria.

Lysozymes are ancient and important components of the innate immune system of animals that hydrolyze peptidoglycan, the major bacterial cell wall polymer. Bacteria engaging in commensal or pathogenic interactions with an animal host have evolved various strategies to evade this bactericidal enzyme,...

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Bibliographic Details
Main Authors: Lien Callewaert, Abram Aertsen, Daphne Deckers, Kristof G A Vanoirbeek, Lise Vanderkelen, Joris M Van Herreweghe, Barbara Masschalck, Dorothy Nakimbugwe, Johan Robben, Chris W Michiels
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2008-03-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC2267010?pdf=render