Extremely high Tp53 mutation load in esophageal squamous cell carcinoma in Golestan Province, Iran.

Golestan Province in northeastern Iran has one of the highest incidences of esophageal squamous cell carcinoma (ESCC) in the world with rates over 50 per 100,000 person-years in both sexes. We have analyzed TP53 mutation patterns in tumors from this high-risk geographic area in search of clues to th...

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Bibliographic Details
Main Authors: Behnoush Abedi-Ardekani, Farin Kamangar, Masoud Sotoudeh, Stephanie Villar, Farhad Islami, Karim Aghcheli, Dariush Nasrollahzadeh, Noushin Taghavi, Sanford M Dawsey, Christian C Abnet, Stephen M Hewitt, Saman Fahimi, Farrokh Saidi, Paul Brennan, Paolo Boffetta, Reza Malekzadeh, Pierre Hainaut
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3246475?pdf=render