Protective effects and mechanisms of high-dose vitamin C on sepsis-associated cognitive impairment in rats

Abstract Sepsis survivors present long-term cognitive deficits. The present study was to investigate the effect of early administration of high-dose vitamin C on cognitive function in septic rats and explore its possible cerebral protective mechanism. Rat sepsis models were established by cecal liga...

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Bibliographic Details
Main Authors: Ning Zhang, Wei Zhao, Zhen-Jie Hu, Sheng-Mei Ge, Yan Huo, Li-Xia Liu, Bu-Lang Gao
Format: Article
Language:English
Published: Nature Publishing Group 2021-07-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-93861-x