TFEB Promotes Prostate Cancer Progression via Regulating ABCA2-Dependent Lysosomal Biogenesis

TFEB Promotes Prostate Cancer Progression via Regulating ABCA2-Dependent Lysosomal Biogenesis

Transcription factor EB (TFEB), a member of the MiT family, is dysregulated in different cancers and exerts specific biological functions within the tumor microenvironment. Downregulation of TFEB induces macrophage polarization in the TME and promotes tumor progression. However, the biological role...

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Bibliographic Details
Main Authors: Xuejin Zhu, Yangjia Zhuo, Shulin Wu, Yanfei Chen, Jianheng Ye, Yulin Deng, Yuanfa Feng, Ren Liu, Shanghua Cai, Zhihao Zou, Bin Wang, Chin-Lee Wu, Guohua Zeng, Weide Zhong
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Oncology
Subjects:
TFEB
ABCA2
prostate cancer
tumor microenvironment
lysosomal biogenesis
biochemical recurrence
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.632524/full

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https://www.frontiersin.org/articles/10.3389/fonc.2021.632524/full

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