Potential role of tocilizumab in severe gastrointestinal barrier damage after CAR T-cell therapy

Potential role of tocilizumab in severe gastrointestinal barrier damage after CAR T-cell therapy

We report a septicemia and disseminated candidiasis due to delayed gastrointestinal mucosae repair in a patient treated with tocilizumab after anti-CD19 CAR T-cell therapy. Tocilizumab could have inhibited intestinal tissue repair and furthered bacteria translocation leading to the invasion of intes...

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Bibliographic Details
Main Authors: David Beauvais, Oriane Karleskind, Severine Loridant, Remy Nyga, Marie Lamiaux, Anne-Sophie Moreau, Franck Morschhauser, Suman Mitra, Ibrahim Yakoub-Agha, Boualem Sendid
Format: Article
Language:English
Published: Elsevier 2021-04-01
Series:Journal of Microbiology, Immunology and Infection
Subjects:
CAR T-cell
Il-6
tocilizumab
Online Access:http://www.sciencedirect.com/science/article/pii/S1684118221000499

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http://www.sciencedirect.com/science/article/pii/S1684118221000499

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