Interplay of Energetics and ER Stress Exacerbates Alzheimer's Amyloid-β (Aβ) Toxicity in Yeast

Interplay of Energetics and ER Stress Exacerbates Alzheimer's Amyloid-β (Aβ) Toxicity in Yeast

Alzheimer's disease (AD) is a progressive neurodegeneration. Oligomers of amyloid-β peptides (Aβ) are thought to play a pivotal role in AD pathogenesis, yet the mechanisms involved remain unclear. Two major isoforms of Aβ associated with AD are Aβ40 and Aβ42, the latter being more toxic and pro...

Full description

Bibliographic Details
Main Authors: Xin Chen, Markus M. M. Bisschops, Nisha R. Agarwal, Boyang Ji, Kumaravel P. Shanmugavel, Dina Petranovic
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-07-01
Series:Frontiers in Molecular Neuroscience
Subjects:
amyloid-β
Alzheimer's disease
energetics
ER stress
yeast
Online Access:http://journal.frontiersin.org/article/10.3389/fnmol.2017.00232/full

Internet

http://journal.frontiersin.org/article/10.3389/fnmol.2017.00232/full

Similar Items