Nr4a1 and Nr4a3 Reporter Mice Are Differentially Sensitive to T Cell Receptor Signal Strength and Duration

Nr4a1 and Nr4a3 Reporter Mice Are Differentially Sensitive to T Cell Receptor Signal Strength and Duration

Summary: Nr4a receptors are activated by T cell receptor (TCR) signaling and play key roles in T cell differentiation. Which TCR signaling pathways regulate Nr4a receptors and their sensitivities to TCR signal strength and duration remains unclear. Using Nr4a1/Nur77-GFP and Nr4a3-Timer of cell kinet...

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Bibliographic Details
Main Authors: Emma Jennings, Thomas A.E. Elliot, Natasha Thawait, Shivani Kanabar, Juan Carlos Yam-Puc, Masahiro Ono, Kai-Michael Toellner, David C. Wraith, Graham Anderson, David Bending
Format: Article
Language:English
Published: Elsevier 2020-11-01
Series:Cell Reports
Subjects:
T cell receptor signaling
Nr4a1-GFP
Nr4a3-Tocky
NFAT
T cell development
T cell activation
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124720313176

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http://www.sciencedirect.com/science/article/pii/S2211124720313176

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