A lympho-follicular microenvironment is required for pathological prion protein deposition in chronically inflamed tissues from scrapie-affected sheep.

A lympho-follicular microenvironment is required for pathological prion protein deposition in chronically inflamed tissues from scrapie-affected sheep.

In sheep scrapie, pathological prion protein (PrP(Sc)) deposition occurs in the lymphoreticular and central nervous systems. We investigated PrP(Sc) distribution in scrapie-affected sheep showing simultaneous evidence of chronic lymphofollicular, lymphoproliferative/non-lymphofollicular, and/or gran...

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Main Authors: Caterina Maestrale, Giovanni Di Guardo, Maria Giovanna Cancedda, Giuseppe Marruchella, Mariangela Masia, Stefania Sechi, Simonetta Macciocu, Cinzia Santucciu, Mara Petruzzi, Ciriaco Ligios
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3643908?pdf=render

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http://europepmc.org/articles/PMC3643908?pdf=render

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