And Yet It Moves: Oxidation of the Nuclear Autoantigen La/SS-B Is the Driving Force for Nucleo-Cytoplasmic Shuttling

And Yet It Moves: Oxidation of the Nuclear Autoantigen La/SS-B Is the Driving Force for Nucleo-Cytoplasmic Shuttling

Decades ago, we and many other groups showed a nucleo-cytoplasmic translocation of La protein in cultured cells. This shuttling of La protein was seen after UV irradiation, virus infections, hydrogen peroxide exposure and the Fenton reaction based on iron or copper ions. All of these conditions are...

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Bibliographic Details
Main Authors: Nicole Berndt, Claudia C. Bippes, Irene Michalk, Tabea Bartsch, Claudia Arndt, Edinson Puentes-Cala, Javier Andrés Soto, Liliana R. Loureiro, Alexandra Kegler, Dominik Bachmann, Joanne K. Gross, Tim Gross, Biji T. Kurien, R. Hal Scofield, A. Darise Farris, Judith A. James, Ralf Bergmann, Marc Schmitz, Anja Feldmann, Michael P. Bachmann
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:International Journal of Molecular Sciences
Subjects:
anti-La/SS-B antibodies
autoimmunity
La/SS-B autoantigen
systemic lupus erythematosus
primary Sjögren’s Syndrome
redox sensor
Online Access:https://www.mdpi.com/1422-0067/22/18/9699

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https://www.mdpi.com/1422-0067/22/18/9699

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