The Impact of Binge Drinking on Mortality and Liver Disease in the Swiss HIV Cohort Study
<b> </b>Whereas excessive alcohol consumption increases liver disease incidence and mortality, evidence on the risk associated with specific drinking patterns is emerging. We assessed the impact of binge drinking on mortality and liver disease in the Swiss HIV Cohort Study. All participa...
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doaj-2b5814eae78f4315a75b8b17c7d6fa9a2021-01-15T00:05:25ZengMDPI AGJournal of Clinical Medicine2077-03832021-01-011029529510.3390/jcm10020295The Impact of Binge Drinking on Mortality and Liver Disease in the Swiss HIV Cohort StudyBernard Surial0Nicolas Bertholet1Jean-Bernard Daeppen2Katharine E. A. Darling3Alexandra Calmy4Huldrych F. Günthard5Marcel Stöckle6Enos Bernasconi7Patrick Schmid8Andri Rauch9Hansjakob Furrer10Gilles Wandeler11the Swiss HIV Cohort StudyDepartment of Infectious Diseases, Inselspital, Bern University Hospital, University of Bern, 3010 Bern, SwitzerlandAddiction Medicine, Department of Psychiatry, Lausanne University Hospital, University of Lausanne, 1011 Lausanne, SwitzerlandAddiction Medicine, Department of Psychiatry, Lausanne University Hospital, University of Lausanne, 1011 Lausanne, SwitzerlandDivision of Infectious Diseases, University Hospital of Lausanne, University of Lausanne, 1011 Lausanne, SwitzerlandDivision of Infectious Diseases, Geneva University Hospital, University of Geneva, 1205 Geneva, SwitzerlandDivision of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, University of Zurich, 8091 Zurich, SwitzerlandDivision of Infectious Diseases and Hospital Epidemiology, University Hospital Basel, University of Basel, 4031 Basel, SwitzerlandDivision of Infectious Diseases, Regional Hospital of Lugano, 6903 Lugano, SwitzerlandDivision of Infectious Diseases, Cantonal Hospital of St Gallen, 9007 St. Gallen, SwitzerlandDepartment of Infectious Diseases, Inselspital, Bern University Hospital, University of Bern, 3010 Bern, SwitzerlandDepartment of Infectious Diseases, Inselspital, Bern University Hospital, University of Bern, 3010 Bern, SwitzerlandDepartment of Infectious Diseases, Inselspital, Bern University Hospital, University of Bern, 3010 Bern, Switzerland<b> </b>Whereas excessive alcohol consumption increases liver disease incidence and mortality, evidence on the risk associated with specific drinking patterns is emerging. We assessed the impact of binge drinking on mortality and liver disease in the Swiss HIV Cohort Study. All participants with follow-up between 2013 and 2020 were categorized into one of four drinking pattern groups: “abstinence”, “non-hazardous drinking”, “hazardous but not binge drinking” (Alcohol Use Disorder Identification Test Consumption [AUDIT-C] score ≥3 in women and ≥4 in men), and “binge drinking” (≥6 drinks/occasion more than monthly). We estimated adjusted incidence rate ratios (aIRR) for all-cause mortality, liver-related mortality and liver-related events using multivariable quasi-Poisson regression. Among 11,849 individuals (median follow-up 6.8 years), 470 died (incidence rate 7.1/1000 person-years, 95% confidence interval [CI] 6.5–7.8), 37 experienced a liver-related death (0.6/1000, 0.4–0.8), and 239 liver-related events occurred (3.7/1000, 3.2–4.2). Compared to individuals with non-hazardous drinking, those reporting binge drinking were more likely to die (all-cause mortality: aIRR 1.9, 95% CI 1.3–2.7; liver-related mortality: 3.6, 0.9–13.9) and to experience a liver-related event (3.8, 2.4–5.8). We observed no difference in outcomes between participants reporting non-hazardous and hazardous without binge drinking. These findings highlight the importance of assessing drinking patterns in clinical routine.https://www.mdpi.com/2077-0383/10/2/295alcoholbinge drinkingHIVliver-related outcomesmortality |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Bernard Surial Nicolas Bertholet Jean-Bernard Daeppen Katharine E. A. Darling Alexandra Calmy Huldrych F. Günthard Marcel Stöckle Enos Bernasconi Patrick Schmid Andri Rauch Hansjakob Furrer Gilles Wandeler the Swiss HIV Cohort Study |
spellingShingle |
Bernard Surial Nicolas Bertholet Jean-Bernard Daeppen Katharine E. A. Darling Alexandra Calmy Huldrych F. Günthard Marcel Stöckle Enos Bernasconi Patrick Schmid Andri Rauch Hansjakob Furrer Gilles Wandeler the Swiss HIV Cohort Study The Impact of Binge Drinking on Mortality and Liver Disease in the Swiss HIV Cohort Study Journal of Clinical Medicine alcohol binge drinking HIV liver-related outcomes mortality |
author_facet |
Bernard Surial Nicolas Bertholet Jean-Bernard Daeppen Katharine E. A. Darling Alexandra Calmy Huldrych F. Günthard Marcel Stöckle Enos Bernasconi Patrick Schmid Andri Rauch Hansjakob Furrer Gilles Wandeler the Swiss HIV Cohort Study |
author_sort |
Bernard Surial |
title |
The Impact of Binge Drinking on Mortality and Liver Disease in the Swiss HIV Cohort Study |
title_short |
The Impact of Binge Drinking on Mortality and Liver Disease in the Swiss HIV Cohort Study |
title_full |
The Impact of Binge Drinking on Mortality and Liver Disease in the Swiss HIV Cohort Study |
title_fullStr |
The Impact of Binge Drinking on Mortality and Liver Disease in the Swiss HIV Cohort Study |
title_full_unstemmed |
The Impact of Binge Drinking on Mortality and Liver Disease in the Swiss HIV Cohort Study |
title_sort |
impact of binge drinking on mortality and liver disease in the swiss hiv cohort study |
publisher |
MDPI AG |
series |
Journal of Clinical Medicine |
issn |
2077-0383 |
publishDate |
2021-01-01 |
description |
<b> </b>Whereas excessive alcohol consumption increases liver disease incidence and mortality, evidence on the risk associated with specific drinking patterns is emerging. We assessed the impact of binge drinking on mortality and liver disease in the Swiss HIV Cohort Study. All participants with follow-up between 2013 and 2020 were categorized into one of four drinking pattern groups: “abstinence”, “non-hazardous drinking”, “hazardous but not binge drinking” (Alcohol Use Disorder Identification Test Consumption [AUDIT-C] score ≥3 in women and ≥4 in men), and “binge drinking” (≥6 drinks/occasion more than monthly). We estimated adjusted incidence rate ratios (aIRR) for all-cause mortality, liver-related mortality and liver-related events using multivariable quasi-Poisson regression. Among 11,849 individuals (median follow-up 6.8 years), 470 died (incidence rate 7.1/1000 person-years, 95% confidence interval [CI] 6.5–7.8), 37 experienced a liver-related death (0.6/1000, 0.4–0.8), and 239 liver-related events occurred (3.7/1000, 3.2–4.2). Compared to individuals with non-hazardous drinking, those reporting binge drinking were more likely to die (all-cause mortality: aIRR 1.9, 95% CI 1.3–2.7; liver-related mortality: 3.6, 0.9–13.9) and to experience a liver-related event (3.8, 2.4–5.8). We observed no difference in outcomes between participants reporting non-hazardous and hazardous without binge drinking. These findings highlight the importance of assessing drinking patterns in clinical routine. |
topic |
alcohol binge drinking HIV liver-related outcomes mortality |
url |
https://www.mdpi.com/2077-0383/10/2/295 |
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