Expression Profile of Intravitreous Cytokines, Chemokines and Growth Factors in Patients with Fuchs Heterochromic Iridocyclitis

Purpose: To report the postoperative courses of 2 patients with Fuchs heterochromic iridocyclitis (FHI) and the concentrations of various cytokines, chemokines and growth factors in vitreous fluid samples to obtain insights into pathobiochemical aspects. Subjects: The patients were a 27- and a 47-ye...

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Main Authors: Kaori Suzuki, Yukihiko Suzuki, Mitsuo Matsumoto, Mitsuru Nakazawa
Format: Article
Language:English
Published: Karger Publishers 2010-05-01
Series:Case Reports in Ophthalmology
Subjects:
Online Access:http://www.karger.com/Article/FullText/313842
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spelling doaj-2b6ed89bd329492d937ef97077487ed42020-11-24T22:33:23ZengKarger PublishersCase Reports in Ophthalmology1663-26992010-05-011151310.1159/000313842313842Expression Profile of Intravitreous Cytokines, Chemokines and Growth Factors in Patients with Fuchs Heterochromic IridocyclitisKaori SuzukiYukihiko SuzukiMitsuo MatsumotoMitsuru NakazawaPurpose: To report the postoperative courses of 2 patients with Fuchs heterochromic iridocyclitis (FHI) and the concentrations of various cytokines, chemokines and growth factors in vitreous fluid samples to obtain insights into pathobiochemical aspects. Subjects: The patients were a 27- and a 47-year-old woman. Phacoemulsification and aspiration, intraocular lens (IOL) implantation, and pars plana vitrectomy were performed to treat their cataracts and vitreous opacities. During their early postoperative periods, inflammatory cells precipitated on the IOL and intraocular pressure was increased in both patients. Methods: At the time of surgery, undiluted vitreous fluid specimens were collected. The concentrations of multiple cytokines, chemokines and growth factors were measured by a bead array immunodetection system. Results: The levels of interleukin-1ra, -5, -6, -8, -10 and -13, interferon-inducible 10-kDa protein, monocyte chemoattractant protein 1, macrophage inflammatory protein 1β, and regulated upon activation, normal T-cell expressed and secreted (RANTES) were significantly elevated in vitreous fluid in both patients. Conclusion: Although the postoperative course was generally favorable in patients with FHI, steroid instillation was necessary for a few months postoperatively, as precipitates easily formed on the IOL surface and elevated intraocular pressure. The profiles of intravitreal concentrations of cytokines, chemokines and growth factors may characterize postoperative inflammatory reactions.http://www.karger.com/Article/FullText/313842Fuchs heterochromic iridocyclitisGrowth factorsInterleukinsCytokinesChemokines
collection DOAJ
language English
format Article
sources DOAJ
author Kaori Suzuki
Yukihiko Suzuki
Mitsuo Matsumoto
Mitsuru Nakazawa
spellingShingle Kaori Suzuki
Yukihiko Suzuki
Mitsuo Matsumoto
Mitsuru Nakazawa
Expression Profile of Intravitreous Cytokines, Chemokines and Growth Factors in Patients with Fuchs Heterochromic Iridocyclitis
Case Reports in Ophthalmology
Fuchs heterochromic iridocyclitis
Growth factors
Interleukins
Cytokines
Chemokines
author_facet Kaori Suzuki
Yukihiko Suzuki
Mitsuo Matsumoto
Mitsuru Nakazawa
author_sort Kaori Suzuki
title Expression Profile of Intravitreous Cytokines, Chemokines and Growth Factors in Patients with Fuchs Heterochromic Iridocyclitis
title_short Expression Profile of Intravitreous Cytokines, Chemokines and Growth Factors in Patients with Fuchs Heterochromic Iridocyclitis
title_full Expression Profile of Intravitreous Cytokines, Chemokines and Growth Factors in Patients with Fuchs Heterochromic Iridocyclitis
title_fullStr Expression Profile of Intravitreous Cytokines, Chemokines and Growth Factors in Patients with Fuchs Heterochromic Iridocyclitis
title_full_unstemmed Expression Profile of Intravitreous Cytokines, Chemokines and Growth Factors in Patients with Fuchs Heterochromic Iridocyclitis
title_sort expression profile of intravitreous cytokines, chemokines and growth factors in patients with fuchs heterochromic iridocyclitis
publisher Karger Publishers
series Case Reports in Ophthalmology
issn 1663-2699
publishDate 2010-05-01
description Purpose: To report the postoperative courses of 2 patients with Fuchs heterochromic iridocyclitis (FHI) and the concentrations of various cytokines, chemokines and growth factors in vitreous fluid samples to obtain insights into pathobiochemical aspects. Subjects: The patients were a 27- and a 47-year-old woman. Phacoemulsification and aspiration, intraocular lens (IOL) implantation, and pars plana vitrectomy were performed to treat their cataracts and vitreous opacities. During their early postoperative periods, inflammatory cells precipitated on the IOL and intraocular pressure was increased in both patients. Methods: At the time of surgery, undiluted vitreous fluid specimens were collected. The concentrations of multiple cytokines, chemokines and growth factors were measured by a bead array immunodetection system. Results: The levels of interleukin-1ra, -5, -6, -8, -10 and -13, interferon-inducible 10-kDa protein, monocyte chemoattractant protein 1, macrophage inflammatory protein 1β, and regulated upon activation, normal T-cell expressed and secreted (RANTES) were significantly elevated in vitreous fluid in both patients. Conclusion: Although the postoperative course was generally favorable in patients with FHI, steroid instillation was necessary for a few months postoperatively, as precipitates easily formed on the IOL surface and elevated intraocular pressure. The profiles of intravitreal concentrations of cytokines, chemokines and growth factors may characterize postoperative inflammatory reactions.
topic Fuchs heterochromic iridocyclitis
Growth factors
Interleukins
Cytokines
Chemokines
url http://www.karger.com/Article/FullText/313842
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