Inhibition of PI3K prevents the proliferation and differentiation of human lung fibroblasts into myofibroblasts: the role of class I P110 isoforms.

Inhibition of PI3K prevents the proliferation and differentiation of human lung fibroblasts into myofibroblasts: the role of class I P110 isoforms.

Idiopathic pulmonary fibrosis (IPF) is a progressive fibroproliferative disease characterized by an accumulation of fibroblasts and myofibroblasts in the alveolar wall. Even though the pathogenesis of this fatal disorder remains unclear, transforming growth factor-β (TGF-β)-induced differentiation a...

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Bibliographic Details
Main Authors: Enrico Conte, Mary Fruciano, Evelina Fagone, Elisa Gili, Filippo Caraci, Maria Iemmolo, Nunzio Crimi, Carlo Vancheri
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3184941?pdf=render

Internet

http://europepmc.org/articles/PMC3184941?pdf=render

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