Effect of immunotherapy combined with intravenous chemotherapy on the tumor load, immune function and cancer cell proliferation activity in patients with advanced colon cancer
Objective: To study the effect of immunotherapy combined with intravenous chemotherapy on the tumor load, immune function and cancer cell proliferation activity in patients with advanced colon cancer. Methods: A total of 90 patients with advanced colon cancer who were treated in Second People’s H...
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Format: | Article |
Language: | English |
Published: |
Editorial Board of Journal of Hainan Medical University
2017-09-01
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Series: | Journal of Hainan Medical University |
Subjects: | |
Online Access: | http://www.hnykdxxb.com/PDF/201718/26.pdf |
Summary: | Objective: To study the effect of immunotherapy combined with intravenous chemotherapy
on the tumor load, immune function and cancer cell proliferation activity in patients with
advanced colon cancer. Methods: A total of 90 patients with advanced colon cancer who were
treated in Second People’s Hospital of Yibin between December 2014 and January 2017 were
collected and divided into control group (n=45) and observation group (n=45) by random
number table. Control group received routine intravenous chemotherapy, and the observation
group received immunotherapy combined with intravenous chemotherapy. The levels of
specific tumor markers and Th17/Treg cytokines in serum as well as proliferation gene
expression in the lesion tissue were determined. Results: Before treatment, the differences
in levels of specific tumor markers and Th17/Treg cytokines in serum as well as proliferation
gene expression in lesion tissue were not statistically significant between the two groups.
After treatment, PTN, CCSA-1, IL-17 and IL-23 levels in serum as well as GTPBP4 and
PIK3CB mRNA expression in lesion tissue of both groups of patients were lower than those
before treatment while IL-10 and IL-35 levels in serum as well as FAM96B, MS4A12 and
FRAT1 mRNA expression in lesion tissue were higher than those before treatment, and PTN,
CCSA-1, IL-17 and IL-23 levels in serum as well as GTPBP4 and PIK3CB mRNA expression
in lesion tissue of observation group were lower than those of control group while IL-10 and
IL-35 levels in serum as well as FAM96B, MS4A12 and FRAT1 mRNA expression in lesion
tissue were higher than those of control group. Conclusion: Immunotherapy combined with
intravenous chemotherapy can effectively reduce the tumor load, optimize cellular immune
function and inhibit tumor cell proliferation in patients with advanced colon cancer. |
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ISSN: | 1007-1237 1007-1237 |