Cytomorphology of Noninvasive Follicular Thyroid Neoplasm with Papillary-Like Nuclear Features and the Impact of New Nomenclature on Molecular Testing
The re-naming of noninvasive follicular variant papillary thyroid cancer to the apparently non-malignant, noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) impacts the prevalence of malignancy rates, thereby affecting mutation frequency in papillary thyroid cancer....
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doaj-2ca2bbbc840a4bf1828780d64f2357b32020-11-25T00:03:26ZengMDPI AGMedical Sciences2076-32712019-01-01721510.3390/medsci7020015medsci7020015Cytomorphology of Noninvasive Follicular Thyroid Neoplasm with Papillary-Like Nuclear Features and the Impact of New Nomenclature on Molecular TestingRupendra T. Shrestha0Darin Ruanpeng1James V. Hennessey2University of Minnesota Twin Cities, Department of Medicine, Minneapolis, MN 55455, USAUniversity of Minnesota Twin Cities, Department of Medicine, Minneapolis, MN 55455, USADivision of Endocrinology, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, GZ-6, Boston, MA 02215, USAThe re-naming of noninvasive follicular variant papillary thyroid cancer to the apparently non-malignant, noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) impacts the prevalence of malignancy rates, thereby affecting mutation frequency in papillary thyroid cancer. Preoperative assessment of such nodules could affect management in the future. The original publications following the designation of the new nomenclature have been extensively reviewed. With the adoption of NIFTP terminology, a reduction in the follicular variant of papillary thyroid cancer (FVPTC) prevalence is anticipated, as is a modest reduction of papillary thyroid cancer (PTC) prevalence that would be distributed mainly across indeterminate thyroid nodules. Identifying NIFTP preoperatively remains challenging. <i>RAS</i> mutations are predominant but the presence of <i>BRAF </i>V600E mutation has been observed and could indicate inclusion of the classical PTC. The histological diagnosis of NIFTP to designate low-risk encapsulated follicular variant papillary thyroid cancers (EFVPTCs) would impact malignancy rates, thereby altering the mutation prevalence. The histopathologic criteria have recently been refined with an exclusion of well-formed papillae. The preoperative identification of NIFTP using cytomorphology and gene testing remains challenging.https://www.mdpi.com/2076-3271/7/2/15NIFTPnon-invasive follicular thyroid neoplasm with papillary-like nuclear featuresBethesdaFVPTCfollicular variant of Papillary thyroid cancerRASBRAF |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Rupendra T. Shrestha Darin Ruanpeng James V. Hennessey |
spellingShingle |
Rupendra T. Shrestha Darin Ruanpeng James V. Hennessey Cytomorphology of Noninvasive Follicular Thyroid Neoplasm with Papillary-Like Nuclear Features and the Impact of New Nomenclature on Molecular Testing Medical Sciences NIFTP non-invasive follicular thyroid neoplasm with papillary-like nuclear features Bethesda FVPTC follicular variant of Papillary thyroid cancer RAS BRAF |
author_facet |
Rupendra T. Shrestha Darin Ruanpeng James V. Hennessey |
author_sort |
Rupendra T. Shrestha |
title |
Cytomorphology of Noninvasive Follicular Thyroid Neoplasm with Papillary-Like Nuclear Features and the Impact of New Nomenclature on Molecular Testing |
title_short |
Cytomorphology of Noninvasive Follicular Thyroid Neoplasm with Papillary-Like Nuclear Features and the Impact of New Nomenclature on Molecular Testing |
title_full |
Cytomorphology of Noninvasive Follicular Thyroid Neoplasm with Papillary-Like Nuclear Features and the Impact of New Nomenclature on Molecular Testing |
title_fullStr |
Cytomorphology of Noninvasive Follicular Thyroid Neoplasm with Papillary-Like Nuclear Features and the Impact of New Nomenclature on Molecular Testing |
title_full_unstemmed |
Cytomorphology of Noninvasive Follicular Thyroid Neoplasm with Papillary-Like Nuclear Features and the Impact of New Nomenclature on Molecular Testing |
title_sort |
cytomorphology of noninvasive follicular thyroid neoplasm with papillary-like nuclear features and the impact of new nomenclature on molecular testing |
publisher |
MDPI AG |
series |
Medical Sciences |
issn |
2076-3271 |
publishDate |
2019-01-01 |
description |
The re-naming of noninvasive follicular variant papillary thyroid cancer to the apparently non-malignant, noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) impacts the prevalence of malignancy rates, thereby affecting mutation frequency in papillary thyroid cancer. Preoperative assessment of such nodules could affect management in the future. The original publications following the designation of the new nomenclature have been extensively reviewed. With the adoption of NIFTP terminology, a reduction in the follicular variant of papillary thyroid cancer (FVPTC) prevalence is anticipated, as is a modest reduction of papillary thyroid cancer (PTC) prevalence that would be distributed mainly across indeterminate thyroid nodules. Identifying NIFTP preoperatively remains challenging. <i>RAS</i> mutations are predominant but the presence of <i>BRAF </i>V600E mutation has been observed and could indicate inclusion of the classical PTC. The histological diagnosis of NIFTP to designate low-risk encapsulated follicular variant papillary thyroid cancers (EFVPTCs) would impact malignancy rates, thereby altering the mutation prevalence. The histopathologic criteria have recently been refined with an exclusion of well-formed papillae. The preoperative identification of NIFTP using cytomorphology and gene testing remains challenging. |
topic |
NIFTP non-invasive follicular thyroid neoplasm with papillary-like nuclear features Bethesda FVPTC follicular variant of Papillary thyroid cancer RAS BRAF |
url |
https://www.mdpi.com/2076-3271/7/2/15 |
work_keys_str_mv |
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