Conservation of uORF repressiveness and sequence features in mouse, human and zebrafish

Upstream open reading frames (uORFs) can repress gene expression. Here, Guo-Liang Chew and colleagues use bioinformatics approaches to show that conservation of uORF-mediated translational repression is mediated by sequence features in human, mouse and zebrafish genomes.

Bibliographic Details
Main Authors:	Guo-Liang Chew, Andrea Pauli, Alexander F. Schier
Format:	Article
Language:	English
Published:	Nature Publishing Group 2016-05-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/ncomms11663

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spelling	doaj-2cc05969e6f84064a5e5c7b84f3be8e52021-05-11T11:04:33ZengNature Publishing GroupNature Communications2041-17232016-05-017111010.1038/ncomms11663Conservation of uORF repressiveness and sequence features in mouse, human and zebrafishGuo-Liang Chew0Andrea Pauli1Alexander F. Schier2Department of Molecular and Cellular Biology, Harvard UniversityDepartment of Molecular and Cellular Biology, Harvard UniversityDepartment of Molecular and Cellular Biology, Harvard UniversityUpstream open reading frames (uORFs) can repress gene expression. Here, Guo-Liang Chew and colleagues use bioinformatics approaches to show that conservation of uORF-mediated translational repression is mediated by sequence features in human, mouse and zebrafish genomes.https://doi.org/10.1038/ncomms11663
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Guo-Liang Chew Andrea Pauli Alexander F. Schier
spellingShingle	Guo-Liang Chew Andrea Pauli Alexander F. Schier Conservation of uORF repressiveness and sequence features in mouse, human and zebrafish Nature Communications
author_facet	Guo-Liang Chew Andrea Pauli Alexander F. Schier
author_sort	Guo-Liang Chew
title	Conservation of uORF repressiveness and sequence features in mouse, human and zebrafish
title_short	Conservation of uORF repressiveness and sequence features in mouse, human and zebrafish
title_full	Conservation of uORF repressiveness and sequence features in mouse, human and zebrafish
title_fullStr	Conservation of uORF repressiveness and sequence features in mouse, human and zebrafish
title_full_unstemmed	Conservation of uORF repressiveness and sequence features in mouse, human and zebrafish
title_sort	conservation of uorf repressiveness and sequence features in mouse, human and zebrafish
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2016-05-01
description	Upstream open reading frames (uORFs) can repress gene expression. Here, Guo-Liang Chew and colleagues use bioinformatics approaches to show that conservation of uORF-mediated translational repression is mediated by sequence features in human, mouse and zebrafish genomes.
url	https://doi.org/10.1038/ncomms11663
work_keys_str_mv	AT guoliangchew conservationofuorfrepressivenessandsequencefeaturesinmousehumanandzebrafish AT andreapauli conservationofuorfrepressivenessandsequencefeaturesinmousehumanandzebrafish AT alexanderfschier conservationofuorfrepressivenessandsequencefeaturesinmousehumanandzebrafish
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Conservation of uORF repressiveness and sequence features in mouse, human and zebrafish

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