IL-4 receptor alpha single-nucleotide polymorphisms rs1805010 and rs1801275 are associated with increased risk of asthma in a Saudi Arabian population

IL-4 receptor alpha single-nucleotide polymorphisms rs1805010 and rs1801275 are associated with increased risk of asthma in a Saudi Arabian population

Background: The IL-4 receptor alpha subunit (IL-4Rα), when associated with the common gamma chain receptor, or the IL-13Rα1 subunit, transduces signals to STAT6 in response to IL-4 and IL-13 stimulations. This results in a number of cell-specific responses including Th2 differentiation, lymphocyte p...

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Bibliographic Details
Main Authors: Saleh Al-Muhsen, Alejandro Vazquez-Tello, Ashraf Alzaabi, Mohamed S Al-Hajjaj, Hamdan H Al-Jahdali, Rabih Halwani
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2014-01-01
Series:Annals of Thoracic Medicine
Subjects:
Asthma
allergy
association
genotype
IL-4 receptor alpha
susceptibility
STAT6
Online Access:http://www.thoracicmedicine.org/article.asp?issn=1817-1737;year=2014;volume=9;issue=2;spage=81;epage=86;aulast=Al-Muhsen

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http://www.thoracicmedicine.org/article.asp?issn=1817-1737;year=2014;volume=9;issue=2;spage=81;epage=86;aulast=Al-Muhsen

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