High Persister Mutants in Mycobacterium tuberculosis.

Mycobacterium tuberculosis forms drug-tolerant persister cells that are the probable cause of its recalcitrance to antibiotic therapy. While genetically identical to the rest of the population, persisters are dormant, which protects them from killing by bactericidal antibiotics. The mechanism of per...

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Bibliographic Details
Main Authors: Heather L Torrey, Iris Keren, Laura E Via, Jong Seok Lee, Kim Lewis
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4866775?pdf=render