Interferon-gamma promotes infection of astrocytes by Trypanosoma cruzi.

The inflammatory cytokine interferon-gamma (IFNγ) is crucial for immunity against intracellular pathogens such as the protozoan parasite Trypanosoma cruzi, the causative agent of Chagas disease (CD). IFNγ is a pleiotropic cytokine which regulates activation of immune and non-immune cells; however, t...

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Bibliographic Details
Main Authors: Rafael Rodrigues Silva, Rafael M Mariante, Andrea Alice Silva, Ana Luiza Barbosa dos Santos, Ester Roffê, Helton Santiago, Ricardo Tostes Gazzinelli, Joseli Lannes-Vieira
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0118600