Mechanism of TRIM25 Catalytic Activation in the Antiviral RIG-I Pathway

Mechanism of TRIM25 Catalytic Activation in the Antiviral RIG-I Pathway

Antiviral response pathways induce interferon by higher-order assembly of signaling complexes called signalosomes. Assembly of the RIG-I signalosome is regulated by K63-linked polyubiquitin chains, which are synthesized by the E3 ubiquitin ligase, TRIM25. We have previously shown that the TRIM25 coi...

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Bibliographic Details
Main Authors: Jacint G. Sanchez, Jessica J. Chiang, Konstantin M.J. Sparrer, Steven L. Alam, Michael Chi, Marcin D. Roganowicz, Banumathi Sankaran, Michaela U. Gack, Owen Pornillos
Format: Article
Language:English
Published: Elsevier 2016-08-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124716308397

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http://www.sciencedirect.com/science/article/pii/S2211124716308397

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