Adipocyte-Mineralocorticoid Receptor Alters Mitochondrial Quality Control Leading to Mitochondrial Dysfunction and Senescence of Visceral Adipose Tissue

Adipocyte-Mineralocorticoid Receptor Alters Mitochondrial Quality Control Leading to Mitochondrial Dysfunction and Senescence of Visceral Adipose Tissue

Mineralocorticoid receptor (MR) expression is increased in the adipose tissue (AT) of obese patients and animals. We previously demonstrated that adipocyte-MR overexpression in mice (Adipo-MROE mice) is associated with metabolic alterations. Moreover, we showed that MR regulates mitochondrial dysfun...

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Bibliographic Details
Main Authors: Clara Lefranc, Malou Friederich-Persson, Fabienne Foufelle, Aurélie Nguyen Dinh Cat, Frédéric Jaisser
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:International Journal of Molecular Sciences
Subjects:
mineralocorticoid receptor
mitochondrial dysfunction
adipose tissue
oxidative stress
senescence
metabolic syndrome
Online Access:https://www.mdpi.com/1422-0067/22/6/2881

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