LRIG proteins regulate lipid metabolism via BMP signaling and affect the risk of type 2 diabetes

LRIG proteins regulate lipid metabolism via BMP signaling and affect the risk of type 2 diabetes

Herdenberg et al. show that adipogenesis and BMP signaling are altered in mouse cells deficient in LRIG (Leucine-rich repeats and immunoglobulin-like domains) proteins. They find that mutant LRIG/sma-10 variant worms exhibit lipid storage defects and that human LRIG1 variants are associated with hig...

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Bibliographic Details
Main Authors: Carl Herdenberg, Pascal M. Mutie, Ola Billing, Ahmad Abdullah, Rona J. Strawbridge, Ingrid Dahlman, Simon Tuck, Camilla Holmlund, Peter Arner, Roger Henriksson, Paul W. Franks, Håkan Hedman
Format: Article
Language:English
Published: Nature Publishing Group 2021-01-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-020-01613-w

Internet

https://doi.org/10.1038/s42003-020-01613-w

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