Hepatoenteric recycling is a new disposition mechanism for orally administered phenolic drugs and phytochemicals in rats

Hepatoenteric recycling is a new disposition mechanism for orally administered phenolic drugs and phytochemicals in rats

Many orally administered phenolic drugs undergo enterohepatic recycling (EHR), presumably mediated by the hepatic phase II enzymes. However, the disposition of extrahepatically generated phase II metabolites is unclear. This paper aims to determine the new roles of liver and intestine in the disposi...

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Bibliographic Details
Main Authors: Yifan Tu, Lu Wang, Yi Rong, Vincent Tam, Taijun Yin, Song Gao, Rashim Singh, Ming Hu
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-07-01
Series:eLife
Subjects:
hepatology
gastroenterology
drug metabolism
polyphenols
bioavailability
recirculation
Online Access:https://elifesciences.org/articles/58820

Internet

https://elifesciences.org/articles/58820

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