Analysis of the effects of dexmedetomidine on stress responses and circulation of ICU patients with trachea cannula treatment
Objective: To observe the effects of dexmedetomidine on stress responses and circulation of ICU patients with trachea cannula treatment and to discuss its clinical values. Methods: A total of 60 cases who were admitted in our hospital from June 2014 to February 2016 were selected and were randoml...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Editorial Board of Journal of Hainan Medical University
2016-07-01
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| Series: | Journal of Hainan Medical University |
| Subjects: | |
| Online Access: | http://www.hnykdxxb.com/PDF/201614/25.pdf |
| Summary: | Objective: To observe the effects of dexmedetomidine on stress responses and circulation of
ICU patients with trachea cannula treatment and to discuss its clinical values. Methods: A
total of 60 cases who were admitted in our hospital from June 2014 to February 2016 were
selected and were randomly divided into study group and control group (n=30). Intravenous
line of 60 cases was opened before trachea cannula treatment and radial artery puncture was
performed for monitoring the invasive artery blood pressure. Patients in study group were given
dexmedetomidine treatment for 10 min, with pump injection of 0.5 μg•kg-1 ; then patients
in study group were given the right dosage of propofol and cis-atracurium treatment, with
intravenous injection; while patients in control group were given the equivalent normal saline
(NS) treatment with pump injection and then were given the right dosage of propofol and cisatracurium treatment. After mask oxygen inhalation, trachea cannula treatment was performed.
Haemodynamics relevant index changes of both groups at different time were recorded and
arterial blood was collected for determining the cortisol levels for statistical analysis. Results:
The used dosage of propofol and cis-atracurium in both groups had no obvious statistical
significance. MAP and HR levels of patients in study group were (85.5±10.6) mmHg and
(68.5±6.9) times/min respectively immediately after trachea cannula treatment and were
(83.7±9.4) mmHg and (68.4±6.5) times/min respectively 5 min after trachea cannula treatment,
which were lower than that in control group, with (95.2±9.5) mmHg and (75.5±6.6) times/min
respectively immediately after trachea cannula treatment and (92.2±9.6) mmHg and (76.5±7.2)
times/min respectively 5min after trachea cannula treatment, haemodynamics was more stable.
Cortisol levels of patients in study group were (33.4±1.5), (34.1±1.8), (34.5±1.6) respectively
after pump injection of dexmedetomidine, immediately after trachea cannula treatment and
5min after trachea cannula treatment, which were lower than that in control group, with
(34.4±1.6), (35.8±1.7), (35.7±1.5) respectively, and difference had statistical significance.
Conclusion: The clinical application of dexmedetomidine in trachea cannula treatment of
ICU patients could inhibit the stress responses and had smaller effects on circulation, and its
haemodynamics was relatively stable, which had important clinical values. |
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| ISSN: | 1007-1237 1007-1237 |