Hepatoprotective Activity of Dried- and Fermented-Processed Virgin Coconut Oil

Hepatoprotective Activity of Dried- and Fermented-Processed Virgin Coconut Oil

The present study aims to determine the hepatoprotective effect of MARDI-produced virgin coconut oils, prepared by dried- or fermented-processed methods, using the paracetamol-induced liver damage in rats. Liver injury induced by 3 g/kg paracetamol increased the liver weight per 100 g bodyweight ind...

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Main Authors: Z. A. Zakaria, M. S. Rofiee, M. N. Somchit, A. Zuraini, M. R. Sulaiman, L. K. Teh, M. Z. Salleh, K. Long
Format: Article
Language:English
Published: Hindawi Limited 2011-01-01
Series:Evidence-Based Complementary and Alternative Medicine
Online Access:http://dx.doi.org/10.1155/2011/142739
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spelling doaj-2e43c09be5894a3c9d78073f578ca7782020-11-25T01:28:24ZengHindawi LimitedEvidence-Based Complementary and Alternative Medicine1741-427X1741-42882011-01-01201110.1155/2011/142739142739Hepatoprotective Activity of Dried- and Fermented-Processed Virgin Coconut OilZ. A. Zakaria0M. S. Rofiee1M. N. Somchit2A. Zuraini3M. R. Sulaiman4L. K. Teh5M. Z. Salleh6K. Long7Department of Biomedical Sciences, Faculty of Medicine and Health Science, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, MalaysiaFaculty of Pharmacy, Universiti Teknologi MARA, 40450 Shah Alam, Selangor, MalaysiaDepartment of Biomedical Sciences, Faculty of Medicine and Health Science, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, MalaysiaDepartment of Biomedical Sciences, Faculty of Medicine and Health Science, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, MalaysiaDepartment of Biomedical Sciences, Faculty of Medicine and Health Science, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, MalaysiaPharmacogenomics Center, Faculty of Pharmacy, Universiti Teknologi MARA, 40450 Shah Alam, Selangor, MalaysiaPharmacogenomics Center, Faculty of Pharmacy, Universiti Teknologi MARA, 40450 Shah Alam, Selangor, MalaysiaBiotechnology Research Centre, Malaysian Agriculture Research Institute, 50744 Kuala Lumpur, MalaysiaThe present study aims to determine the hepatoprotective effect of MARDI-produced virgin coconut oils, prepared by dried- or fermented-processed methods, using the paracetamol-induced liver damage in rats. Liver injury induced by 3 g/kg paracetamol increased the liver weight per 100 g bodyweight indicating liver damage. Histological observation also confirms liver damage indicated by the presence of inflammations and necrosis on the respective liver section. Interestingly, pretreatment of the rats with 10, but not 1 and 5, mL/kg of both VCOs significantly (P<.05) reduced the liver damage caused by the administration of paracetamol, which is further confirmed by the histological findings. In conclusion, VCO possessed hepatoprotective effect that requires further in-depth study.http://dx.doi.org/10.1155/2011/142739
collection DOAJ
language English
format Article
sources DOAJ
author Z. A. Zakaria
M. S. Rofiee
M. N. Somchit
A. Zuraini
M. R. Sulaiman
L. K. Teh
M. Z. Salleh
K. Long
spellingShingle Z. A. Zakaria
M. S. Rofiee
M. N. Somchit
A. Zuraini
M. R. Sulaiman
L. K. Teh
M. Z. Salleh
K. Long
Hepatoprotective Activity of Dried- and Fermented-Processed Virgin Coconut Oil
Evidence-Based Complementary and Alternative Medicine
author_facet Z. A. Zakaria
M. S. Rofiee
M. N. Somchit
A. Zuraini
M. R. Sulaiman
L. K. Teh
M. Z. Salleh
K. Long
author_sort Z. A. Zakaria
title Hepatoprotective Activity of Dried- and Fermented-Processed Virgin Coconut Oil
title_short Hepatoprotective Activity of Dried- and Fermented-Processed Virgin Coconut Oil
title_full Hepatoprotective Activity of Dried- and Fermented-Processed Virgin Coconut Oil
title_fullStr Hepatoprotective Activity of Dried- and Fermented-Processed Virgin Coconut Oil
title_full_unstemmed Hepatoprotective Activity of Dried- and Fermented-Processed Virgin Coconut Oil
title_sort hepatoprotective activity of dried- and fermented-processed virgin coconut oil
publisher Hindawi Limited
series Evidence-Based Complementary and Alternative Medicine
issn 1741-427X
1741-4288
publishDate 2011-01-01
description The present study aims to determine the hepatoprotective effect of MARDI-produced virgin coconut oils, prepared by dried- or fermented-processed methods, using the paracetamol-induced liver damage in rats. Liver injury induced by 3 g/kg paracetamol increased the liver weight per 100 g bodyweight indicating liver damage. Histological observation also confirms liver damage indicated by the presence of inflammations and necrosis on the respective liver section. Interestingly, pretreatment of the rats with 10, but not 1 and 5, mL/kg of both VCOs significantly (P<.05) reduced the liver damage caused by the administration of paracetamol, which is further confirmed by the histological findings. In conclusion, VCO possessed hepatoprotective effect that requires further in-depth study.
url http://dx.doi.org/10.1155/2011/142739
work_keys_str_mv AT zazakaria hepatoprotectiveactivityofdriedandfermentedprocessedvirgincoconutoil
AT msrofiee hepatoprotectiveactivityofdriedandfermentedprocessedvirgincoconutoil
AT mnsomchit hepatoprotectiveactivityofdriedandfermentedprocessedvirgincoconutoil
AT azuraini hepatoprotectiveactivityofdriedandfermentedprocessedvirgincoconutoil
AT mrsulaiman hepatoprotectiveactivityofdriedandfermentedprocessedvirgincoconutoil
AT lkteh hepatoprotectiveactivityofdriedandfermentedprocessedvirgincoconutoil
AT mzsalleh hepatoprotectiveactivityofdriedandfermentedprocessedvirgincoconutoil
AT klong hepatoprotectiveactivityofdriedandfermentedprocessedvirgincoconutoil
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