Mutations in fam20b and xylt1 reveal that cartilage matrix controls timing of endochondral ossification by inhibiting chondrocyte maturation.

Mutations in fam20b and xylt1 reveal that cartilage matrix controls timing of endochondral ossification by inhibiting chondrocyte maturation.

Differentiating cells interact with their extracellular environment over time. Chondrocytes embed themselves in a proteoglycan (PG)-rich matrix, then undergo a developmental transition, termed "maturation," when they express ihh to induce bone in the overlying tissue, the perichondrium. He...

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Bibliographic Details
Main Authors: B Frank Eames, Yi-Lin Yan, Mary E Swartz, Daniel S Levic, Ela W Knapik, John H Postlethwait, Charles B Kimmel
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-08-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC3161922?pdf=render

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http://europepmc.org/articles/PMC3161922?pdf=render

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