NIK promotes metabolic adaptation of glioblastoma cells to bioenergetic stress
Abstract Cancers, including glioblastoma multiforme (GBM), undergo coordinated reprogramming of metabolic pathways that control glycolysis and oxidative phosphorylation (OXPHOS) to promote tumor growth in diverse tumor microenvironments. Adaptation to limited nutrient availability in the microenviro...
Main Authors: | Michael L. Kamradt, Ji-Ung Jung, Kathryn M. Pflug, Dong W. Lee, Victor Fanniel, Raquel Sitcheran |
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Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2021-03-01
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Series: | Cell Death and Disease |
Online Access: | https://doi.org/10.1038/s41419-020-03383-z |
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