Siglec-E retards atherosclerosis by inhibiting CD36-mediated foam cell formation

Siglec-E retards atherosclerosis by inhibiting CD36-mediated foam cell formation

Abstract Background The accumulation of lipid-laden macrophages, foam cells, within sub-endothelial intima is a key feature of early atherosclerosis. Siglec-E, a mouse orthologue of human Siglec-9, is a sialic acid binding lectin predominantly expressed on the surface of myeloid cells to transduce i...

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Bibliographic Details
Main Authors: Yaw-Wen Hsu, Fu-Fei Hsu, Ming-Tsai Chiang, Dong-Lin Tsai, Fu-An Li, Takashi Angata, Paul R. Crocker, Lee-Young Chau
Format: Article
Language:English
Published: BMC 2021-01-01
Series:Journal of Biomedical Science
Subjects:
Atherosclerosis
Sialic acid
Siglec-E
Macrophages
CD36
Low-density lipoprotein
Online Access:https://doi.org/10.1186/s12929-020-00698-z

Internet

https://doi.org/10.1186/s12929-020-00698-z

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