Characterizing the Role of Glycogen Synthase Kinase-3α/β in Macrophage Polarization and the Regulation of Pro-Atherogenic Pathways in Cultured Ldlr-/- Macrophages

Characterizing the Role of Glycogen Synthase Kinase-3α/β in Macrophage Polarization and the Regulation of Pro-Atherogenic Pathways in Cultured Ldlr-/- Macrophages

The molecular and cellular mechanisms that link cardiovascular risk factors to the initiation and progression of atherosclerosis are not understood. Recent findings from our laboratory indicate that endoplasmic reticulum (ER) stress signaling through glycogen synthase kinase (GSK)-3α/β induces pro-a...

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Bibliographic Details
Main Authors: Sarvatit Patel, Geoff Werstuck
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Immunology
Subjects:
atherosclerosis
glycogen synthase kinase-3α/β
macrophage polarization
macrophage function
inflammatory response
bone marrow derived macrophages
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.676752/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.676752/full

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