Paternal poly (ADP-ribose) metabolism modulates retention of inheritable sperm histones and early embryonic gene expression.

Paternal poly (ADP-ribose) metabolism modulates retention of inheritable sperm histones and early embryonic gene expression.

To achieve the extreme nuclear condensation necessary for sperm function, most histones are replaced with protamines during spermiogenesis in mammals. Mature sperm retain only a small fraction of nucleosomes, which are, in part, enriched on gene regulatory sequences, and recent findings suggest that...

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Bibliographic Details
Main Authors: Motomasa Ihara, Mirella L Meyer-Ficca, N Adrian Leu, Shilpa Rao, Fan Li, Brian D Gregory, Irina A Zalenskaya, Richard M Schultz, Ralph G Meyer
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-05-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC4014456?pdf=render

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http://europepmc.org/articles/PMC4014456?pdf=render

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