Preparation of 16β-Estradiol Derivative Libraries as Bisubstrate Inhibitors of 17β-Hydroxysteroid Dehydrogenase Type 1 Using the Multidetachable Sulfamate Linker

Preparation of 16β-Estradiol Derivative Libraries as Bisubstrate Inhibitors of 17β-Hydroxysteroid Dehydrogenase Type 1 Using the Multidetachable Sulfamate Linker

Combinatorial chemistry is a powerful tool used to rapidly generate a large number of potentially biologically active compounds. In our goal to develop bisubstrate inhibitors of 17β-hydroxysteroid dehydrogenase type 1 (17β-HSD1) that interact with both the substrate (estrone or estradiol) and the co...

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Bibliographic Details
Main Authors: Donald Poirier, Florian Delagoutte, Marie Bérubé
Format: Article
Language:English
Published: MDPI AG 2010-03-01
Series:Molecules
Subjects:
Solid-phase synthesis
sulfamate linker
steroid
inhibitor
17β-HSD
Online Access:http://www.mdpi.com/1420-3049/15/3/1590/

Internet

http://www.mdpi.com/1420-3049/15/3/1590/

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